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Publications

  1. Stepnov, A., Lopez Tavera, E., Klauer, R., Lincoln, C., Chowreddy, R., Beckham, G., Eijsink, V., Solomon, K., Blenner, M., Vaaje-Kolstad, G.* “Revisiting the activity of two recently reported plastic-acting enzymes” Nature Communications (In Press, 2024).

  2. Rives, D., Peak, C., Blenner, M.* “RNASeq Analysis Highlights ATF6 Pathway Regulators for CHO Cell Engineering: Different Impacts of ATF6β and WFS1 Knockdown on Fed-batch Production of IgG1”. Scientific Reports (In Press, 2024).

  3. Klauer, R., Hansen, A., Wu, D., Monteiro, L., Solomon, K. *, and Blenner, M.* “Biological upcycling of plastic waste” Annual Reviews in Chemical & Biomolecular Engineering (In Press, 2024). 

  4. Brown, J.L.,Ç‚ Rodriguez-Ocasio,E.,Ç‚ Peterson,C.A.,Ç‚ Blenner, M.A., Smith,R.G., Jarboe, L.R.*, Brown, R.C.* “High-temperature noncatalytic oxidation of polyethylene to a fermentation substrate robustly utilized by Candida maltosa”. ACS Sustainable Chemistry & Engineering 11:50, 17778-17786 (2023).

  5. Agrawal, A.Ç‚, Yang, Z.Ç‚, Blenner, M.* “Metabolic Engineering of geraniol production in Yarrowia lipolytica” Metabolic Engineering Communications 17:e00228 (2023).

  6. Ganesan, V., Monteiro, L., Pedada, D., Stohr, A., Blenner, M* “High-efficiency multiplexed cytosine base editors for natural product biosynthesis in Yarrowia lipolytica” ACS Synthetic Biology 12:10 3082-3091 (2023).

  7. McCarthy, M.E., Dodd, W.B., Lu., X., Pritko, D., Patel, N., Haskel, C., Sanabria, H., Blenner, M., Birtwistle, M.R.* “A Theory for Non-Destructive, High-Throughput Genetic and Genetic Interaction Screening in Single Cells.” ACS Synthetic Biology 12:8 2290-2300 (2023).

  8. Wintenberg, M., Manglass, L., Martinez, N., Blenner, M.* “Global transcriptional response of Escherichia coli exposed in situ to different low-dose ionizing radiation sources” mSystems 8:2 (2023).

  9. Manglass, L., Wintenberg, M., Blenner, M. Martinez, N.*, “Flowthrough of Pu-239 and Fe-55 during RNA extraction” Journal of Radiological Protection 43:1 (2023).

  10. Wang, W., and Blenner, M.* “Engineering heterologous enzyme secretion in Yarrowia lipolytica”. Microbial Cell Factories 21:134 (2022).

  11. Rodriguez-Ocasio,E.,Ç‚ Khalid, A., Truka, C., Blenner, M.A., Jarboe, L.R.*, “Survey of non-conventional yeasts for lipid biotechnology”. Journal of Industrial Microbiology & Biotechnology 49:4 (2022).

  12. Ham, R., Smother, A., King, K., Napalitano, J., Swann, T., Pekarek, L., Blenner, M.*, Dean, D.*, “Efficient SARS-CoV-2 RT-qPCR Saliva Diagnostic Strategy Utilizing Open-Source Pipetting Robots” Journal of Visualized Experiments 180, e63395, doi:10.3791/63395 (2022).

  13. Manglass, L., Wintenberg, M., Vogel, C., Blenner, M., Martinez, N. "Accumulation of radio-iron and plutonium, alone and in combination, in Pseudomonas putida grown in liquid cultures" Journal of Radiological Protection 41(4):1199 (2021).

  14. Manglass, L., Wintenberg, M., Blenner, M., Martinez, N.* "Plutonium-239 accumulation in E. coli and P. putida grown in liquid cultures" Health Physics Journal doi: 10.1097 /HP0001455 (2021).

  15. Wang, W., Dasetty, S., Sarupria, S., Blenner, M.* “Rational engineering of low temperature activity in thermoalkalophilic Geobacillus thermocatenulatus lipase”. Biochemical Engineering Journal 174:108093 (2021).

  16. Yaguchi, A., Lee, S., Blenner, M.* “Synthetic biology towards engineering microbial lignin biotransformation” Trends in Biotechnology (In Press, doi.org/10.1016/j.tibtech. 2021.02.003). 

  17. Yang, Z., Blenner, M.* “Genome editing systems across yeast” Current Opinion in Biotechnology 66:255-266 (2020).

  18. Czajka, J., Okumus, B., Blenner, M., Tang, Y.* “Mitigation of genetic drift by fluxome memory during microbial fermentation scale up” Current Opinion in Biotechnology 66:227-235 (2020).

  19. Molin, W., Yaguchi, A., Blenner, M., Saski, C. “Autonomous replication sequences from the Amaranthus palmeri eccDNA replicon enable replication in yeast” BMC Notes 13:330 (2020).

  20. Molin, W., Yaguchi, A., Blenner, M., Saski, C. “The eccDNA Replicon: A heritable, extra-nuclear vehicle that enables gene amplification and glyphosate resistance in Amaranthus palmeri” Plant Cell 32:2132-2140 (2020). 

  21. Yaguchi, A., Lee, S., Franaszek, N., O’Neill, K., Boundy-Mills, K., Blenner, M.*. “Identification of aromatic metabolizing oleaginous yeast”. Journal of Industrial Microbiology & Biotechnology 47:801-813 (2020). 

  22. Iqbal, S., Blenner, M., Alexander Bryant, A., Larsen, J. “Polymersomes for therapeutic delivery of macromolecules: From design to therapeutic applications”. Macromolecules 21:4 1327-1350 (2020).

  23. Ganesan, V. ‡, Spagnuolo, M. ‡, Agrawal, A., Smith, S., Gao, D., Blenner, M.* “Advances and opportunities in gene editing and gene regulation technology for Yarrowia lipolytica” Microbial Cell Factories 18:208 (2019).

  24. Schwartz, C., Cheng, JF., Evans, R., Schwartz, CA., Wagner, JM., Anglin, S., Beitz, A., Pan, W., Lonardi, S., Blenner, M., Alper, H., Yoshikuni, Y., Wheeldon, I.* “Validating genome-wide CRISPR-Cas9 function improves screening in the oleaginous yeast Yarrowia lipolytica” Metabolic Engineering 55:9 102-110 (2019).

  25. Spagnuolo, M., Yaguchi, A., Blenner, M.* “Engineering of oleaginous yeast for biofuels production: recent advances and future directions.” Current Opinion in Biotechnology 57:73-81 (2019).

  26. Gao, D., Smith, S., Rodriguez, G., Shabbir Hussain, M., Blenner, M.* “Dual CRISPR-Cas9 Cleavage in Yarrowia lipolytica Leads to Efficient Gene Excision and Targeted Integration”, Biotechnology Journal 13:9 1-8 (2018) doi: 10.1002/biot.201700590. 

  27. Spagnuolo, M., Shabbir Hussain M., Gambill L., Blenner, M.*, “Alternative Substrate Metabolism in Yarrowia lipolytica”, Frontiers in Microbiology 9:1077 (2018).

  28. Brabender, M., Shabbir Hussain, M., Rodriguez, G., Blenner, M.* “Urea and Urine are Efficient Nitrogen Sources for Growth of Yarrowia lipolytica”, Applied Microbiology and Biotechnology 102(5):2313-2322 (2018) DOI: 10.1007/s00253-018-8769-z

  29. Yaguchi, A., Spagnuolo, M., Blenner, M*. “Engineering Yeast for Utilization of Alternative Feedstocks” Current Opinion in Biotechnology 53:122-129 (2018).

  30. Yaguchi, A., Robinson A., Mihealsick E., Blenner, M.* “Metabolism of Aromatic Compounds by Trichosporon oleaginosus While Remaining Oleaginous”, Microbial Cell Factories 16:206 (2017) DOI: 10.1186/s12934-017-0820-8

  31. Dasetty, S., Blenner, M.*, Sarupria, S.* “Engineering Lipases: Walking the Fine Line Between Activity and Stability” Materials Research Express – Emerging Investigators Awards Series 4:114008 (2017) DOI: 10.1088/2053-1591/aa9946

  32. Shabbir Hussain, M., Wheeldon, I., Blenner, M.* “A Strong Hybrid Fatty Acid Inducible Transcriptional Sensor Built from Yarrowia lipolytica Upstream Activating and Regulatory Sequences”, Biotechnology Journal 12(1):1-11 (2017). DOI: 10.1002/biot.201700248. Research is featured on the inside cover.

  33. Bulutoglu, B., Dooley, K., Szilvay, G., Blenner M., and Banta, S.* “Catch & Release: Fishing for target proteins with an evolved β-roll peptide exhibiting allosteric regulation”, ACS Synthetic Biology 6(9):1732-1741 (2017). DOI: 10.1021/acssynbio.7b00089

  34. Yaguchi, A.‡, Rives, D.‡, Blenner, M.* “The New Kids on the Block: Emerging Oleaginous Yeast of Biotechnological Importance”, AIMS Microbiology 3(2):186-206 (2017). Top 4 most read in 2017.

  35. Schwartz, C., Shabbir-Hussain, M., Frogue, K., Blenner, M., Wheeldon, I.* “Standardized markerless gene integration for pathway engineering in Yarrowia lipolytica”, ACS Synthetic Biology 6(3):402-409 (2017). ISI Highly Cited.

  36. Shabbir Hussain, M.‡, Rodriguez, G.‡, Gao. D., Spagnuolo M., Gambill, L., Blenner, M.* “Recent Advances in Bioengineering of the Oleaginous Yeast Yarrowia lipolytica”, AIMS Bioengineering 3(4):493-514 (2016).

  37. Rodriguez, G.‡, Shabbir Hussain, M.‡, Gambill L., Gao, D., Yaguchi, A., Blenner, M.* “Engineering Xylose Utilization in Yarrowia lipolytica by Understanding its Cryptic Xylose Pathway”, Biotechnology for Biofuels 9:149 (2016).

  38. Schwartz, C., Shabbir-Hussain, M., Blenner, M., Wheeldon, I.* “Synthetic RNA Polymerase III Promoters Facilitate High Efficiency CRISPR-Cas9 Mediated Genome Editing in Yarrowia lipolytica”, ACS Synthetic Biology5(4):356-359. (2016). Paper is most read during past 12 months in 2016-2017. ISI Highly Cited.

  39. Shabbir Hussain, M., Gambill L., Smith, S., Blenner, M.* “Engineering Promoter Architecture in Oleaginous Yeast Yarrowia lipolytica”, ACS Synthetic Biology, 5(3):213-223. (2016). Research is featured on the cover of the March 2016 issue.

  40. Wilson, A., Blenner, M., Guiseppi-Elie, A.* “Polyplex Formation Influences Release Mechanism of Mono- and Di-Valent Ions from Phosphorylcholine Group Bearing Hydrogels”, Polymers, 6, 2451-2472 (2014).

  41. Nedumpully-Govindan, P., Lin, L., Alexov, E., Blenner, M., Ding, F*. “Structural and Energetic Determinants of Tyrosylprotein Sulfotransferase Specificity”. Bioinformatics, 15(30):2302-2309 (2014).

  42. Blenner, M., Dong, X., Springer, T*. “The structural basis of regulation of von Willebrand Factor binding to glycoprotein Ib”, J. Biological Chemistry, 289:5565-5579 (2014).

  43. Shur, O., Dooley, K., Blenner, M., Baltimore, M., Banta, S*. “A designed, phase changing RTX-based peptide for efficient bioseparations”, Biotechniques, 54(4):197-206 (2013). 

  44. Banta, S.*, Wheeldon, I., Blenner, M. “Protein engineering in the development of functional hydrogels” Annual Reviews in Biomedical Engineering, 12, 167-186 (2010)

  45. Blenner, M., Shur, O., Szilvay, G., Cropeck, D., Banta, S*. (2010), “Calcium induced folding of a Repeat in Toxin (RTX)- Domain Via C-Terminal Entropic Stabilization” Journal of Molecular Biology, 400, 244-256 (2010).

  46. Szilvay, G., Blenner, M., Cropeck, D., Banta, S*. “A FRET-based Method for Probing the Conformational Behavior of an Intrinsically Disordered Repeat Domain from Bordetella pertussis Adenylate Cyclase” Biochemistry, 48, 11273-11282 (2009).

  47. Blenner, M., Banta, S*. “Characterization of the 4D5Flu single chain antibody with a stimulus-responsive elastin-like peptide linker: A potential reporter of peptide linker conformation” Protein Science, 17, 527-536 (2008).

  48. Chockalingam, K., Blenner, M., Banta, S*. “Design and application of stimulus responsive peptide systems” Protein Engineering Design and Selection, 20, 155-61 (2007).

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Books and Monographs

  1. Spagnuolo, M., Blenner, M.* “Gene excision by dual-guide CRISPR-Cas9” Methods in Molecular Biology,Yarrowia lipolytica, Vol 2307, Chapter 5, pg 85-94 (2021).

  2. Spagnuolo, M., Blenner, M.* “Simultaneous gene excision and integration with dual-guide CRISPR-Cas9”Methods in Molecular Biology, Yarrowia lipolytica, Vol 2307, Chapter 4, pg 69-83 (2021).

  3. Blenner, M.* "Enzymatic Deconstruction of Lignin for Biofuels" in Advances in Enzymatic Conversion of Biomass to Biofuels, 1st Edition (2015), Future Medicine Ltd, Montreal Canada.



Patents & Intellectual Property

  1. Yoon, S., Fu, Q., Blenner, M., Doleh, E. “Inducible stable packaging cell line for rAAV production” US 63/662,862 (Patent Application filed June 21, 2024).

  2. Blenner, M., Solomon, K., Klauer, R. “Biological and Biomolecular Recovery of Plastic Waste” US 63/564,161 (Patent Application filed March 12, 2024).

  3. Blenner, M., Sivachandaran, F., Spagnuolo, M. “Microbial Production of Fatty Alcohols Via Spatial Enzyme Localization in the Peroxisomes of Yarrowia lipolytica” US 63/392,900 (Provisional Application- July 28, 2022).

  4. Blenner, M., Solomon, K., Monteiro, L., Singh, J., Klauer, R. “Optimizing Plastic Degradation by Yellow Mealworms and Their Gut Microbiomes” US 63/336,657 (Patent Application filed April 28, 2022, PCT/US2023/066382).

  5. Banta, S*., Blenner, M., Wheeldon, I., Dooley, K. “Leucine Beta Roll Domains And Uses Thereof” US 9,127,267 B2 (September 2015)


Non-Refereed Journal Publications

  1. Klauer, R., Blenner, M., Solomon, K.* “”Life… finds a way”: Sustainable capture and upcycling of plastics by microbes” National Academy of Engineering Quarterly, 2022.

  2. Blenner, M. “Microbes might be key to a mars mission” Scientific American Blog, 2019.

  3. Blenner, M. “Influence of epigenetics on bioprocessing” , 9:72-76 (2018).

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Publications: Text
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